CD-ELISA uses the microfluidic ranking method and centrifugal force to control the testing solution as it flows into\r\nthe reaction region. The most challenging part of CD-ELISA is controlling the flow process for different biological\r\ntesting solutions, i.e. the controlling sequence for the microfluidic channel valves. The microfluidic channel valve is\r\ntherefore the most important fluid channel structure for CD-ELISA. In this study, we propose a valve design suitable\r\nfor a wide range rotational speeds which can be applied for mass production (molding). Together with supporting\r\nexperiments, simulation based on two-phase flow theory is used in this study, and the feasibility of this novel valve\r\ndesign is confirmed. Influencing design factors for the microfluidic channel valves in CD-ELISA are investigated,\r\nincluding various shapes of the arc, distance d, radius r, the location of the center of the circle, and the contact\r\nangle. From both the experimental results and the simulated results, it is evident that the narrowest channel width\r\nand the contact angle are the primary factors influencing valve burst frequency. These can be used as the main\r\ncontrolling factors during the design.
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